slu-pp-332

SLU-PP-332 is an experimental compound designed to mimic the metabolic effects of exercise by activating estrogen-related receptors (ERRs), particularly ERRα, ERRβ, and ERRγ. This activation leads to increased energy expenditure, enhanced fatty acid oxidation, and improved mitochondrial function.
Published Research:
1. Metabolic Benefits in Obese Mice: A study published in the Journal of Pharmacology and Experimental Therapeutics demonstrated that SLU-PP-332 administration in diet-induced obese or genetically obese (ob/ob) mice resulted in increased energy expenditure and fatty acid oxidation. These metabolic changes were accompanied by decreased fat mass accumulation, suggesting potential therapeutic applications for metabolic disorders. SLU-PP-332 has been shown to promote weight loss and reduce fat accumulation in obese mice without affecting food intake or requiring increased physical activity.
Washington University Profiles
2. Enhanced Exercise Endurance: Research reported in ACS Chemical Biology found that SLU-PP-332 increased the proportion of oxidative muscle fibers in mice, leading to enhanced exercise endurance. This effect was attributed to improved mitochondrial function and cellular respiration in skeletal muscle cells.
Washington University Profiles
3. Potential Treatment for Heart Failure: Studies presented by the American Chemical Society indicated that SLU-PP-332 improved cardiac function in mouse models of heart failure. The compound enhanced mitochondrial ultrastructure and upregulated pathways associated with oxidative phosphorylation and fatty acid metabolism, suggesting its potential as a therapeutic agent for heart failure.
American Chemical Society
 
While these findings are promising, it’s important to note that SLU-PP-332 is still in the preclinical stage of development. Further research, including human clinical trials, is necessary to fully understand its efficacy and safety profile.